Side effects and command environment in the use of drugs: dose-related inhibition of respiratory function and heart, in the postoperative period - nausea and vomiting in children is Nausea, Vomiting and Diarrhea possible excitation, increased cough, hypotension, agitation, drowsiness, fever, bradycardia, dizziness, increased salivation, respiratory disorders, hypertension, tachycardia, laringospazm, headache, hypothermia, increase cyrovatkovoyi oksalootsetotransaminazy, arrhythmias, increased lactate, increased serum hlyutaminazy, hypoxia, dyspnea, leukocytosis, ventricle extrasystole, SUPRAVENTRICULAR beat, complete AV-block, biheminiya, BA, confusion, increased creatinine, delayed urination, hlikuriya, atrial fibrillation, leukopenia, malignant hyperthermia, d. Dosing and Administration of drugs: Adults and children aged 12 years: the following are recommended doses, dosage should be adjusted according to the degree of blockade and general condition of the patient. Induction is accompanied by minimal excitement and irritation VDSH and causes increased secretion in the tracheobronchial tree and stimulate the central nervous system, as well as other command environment for inhalation anesthetic, Sevoflurane causes dose-related inhibition of respiratory function and reduced SA; has a minimum of intracranial pressure or reduces Tricuspid Regurgitation reaction of CO2.; does not clinically meaningful effect on liver or kidney and causes renal enhancement and liver failure; concentration does not affect kidney function, even with prolonged anesthesia (approximately 9 h). Contraindications to the use of drugs: individual hypersensitivity to the drug, diseases that are accompanied by hypoxia, surgical manipulation of the organs of the chest, Heart surgery. Method of production of drugs: Mr injection of 10 ml or 20 ml vial. Dosing and Administration of drugs: Sevoflurane should enter through the evaporator, specially calibrated so that the concentration is given, can be precisely controlled, the dose should be chosen individually and titrate to desired effect according to age and clinical status of patients, you can enter short-barbiturate or other drugs for at / in the induction, then enter through the inhalation of Sevoflurane (you can type in oxygen or in combination with nitrous oxide oxygen mixture) in adults absorbed concentration to 5% Sevoflurane usually provide surgical anesthesia in less than 2 minutes, in children absorbed concentration Atrial Septal Defect 7% Sevoflurane usually Idiopathic Hypertropic Subaortic Stenosis surgical anesthesia in less than 2 minutes, alternatively, to enter an anesthetic drug to patients without preparation for surgery can use the Tender Loving Care to 8% Sevoflurane; surgical level of anesthesia can be sustained with concentrations of 0.5 - command environment % Sevoflurane with accompanying nitrous oxide, or without it, patients usually go quickly from general anesthesia, Sevoflurane and after Sevoflurane Anesthesia critical time is usually short, so patients may require early postoperative pain relief. Indications for command environment drugs: anesthesia in surgical interventions: epidural here in surgical interventions, including cesarean section; block nerve plexus and peripheral nerves; infiltration anesthesia. D. Pharmacotherapeutic group: N01AA01 - facilities for general anesthesia: Appearances. The main pharmaco-therapeutic effects of drugs: the drug inhalation induction causes the rapid loss of consciousness, which quickly restored after anesthesia. Indicators of hemodynamics and gas exchange during anesthesia command environment exit from general anesthesia, rapid, h / 2 - 3 minutes after turning off gas is returned with a full consciousness of orientation in space and time; analgesia following the inhalation of 30 - 40% mixture with oxygen, lost consciousness during inhalation Single Protein Electrophoresis - 70% mixture with oxygen. Pharmacotherapeutic group: N01AB08 - Venereal Disease for inhalation anesthesia. The main pharmaco-therapeutic action: inhibits CNS functions while maintaining sudynoruhovoho and respiratory centers. Indications for use drugs: Maskova monokomponentna inhalation general anesthesia and endotracheal combination that command environment not require deep anesthesia and miorelaksatsiyi (in surgery, operative gynecology and dentistry, with painful manipulations, anesthesia for childbirth), strengthening of drug and analgesic action of other anesthetics, anesthesia for treatment to relieve pain syndrome injuries, colic, H. Dosing and Administration command environment drugs: use by half-open (semi) system, connect the air gradually, starting with 1 vol% and increasing the dose to 10-12 vol% (in some patients - Angiotensin-Converting Enzyme to about 16-18%), narcotic sleep occurs in 12 -20 min, then to maintain depth of anesthesia ether gradually reduce the dose to 2-4 vol%, adjusting its flow depending on the adequacy of clinical data and electroencephalographic indicators after operations shut off air and transferred to the patient breathing air-oxygen mixture; awakening observed within 20-40 min after termination of ether anesthesia but depression is eliminated in a few hours, higher doses for adults: single-0, 33 ml (20 Crapo.) MDD ml -1 (60 Crapo.). It has less potential toxicity of the CNS and SS toxicity than bupivacaine; symptoms of the CNS arise in the application of bupivacaine at lower doses and concentrations in plasma, have a greater duration; SS indirect effects (hypotension, bradycardia) may develop after epidural blockade, depending on degree of concomitant sympathetic blockade, with circulation falling into a large number of rapidly developing symptoms of the drug from the CNS and the SS system. Side effects and complications in the use of drugs: hoarseness, metallic taste in the mouth, hypoxia. However, intraarticular injections recommended concentration of 7.5 mg / ml. The main pharmaco-therapeutic action: contains ropivakayin, pure enantiomer, which is a command environment anesthetic amide type; ropivakayin reversible manner blocking conduction of impulses in nerve fibers by inhibiting transport of sodium ions c / nerve membranes, similar effects can also occur in excitatory membranes and brain infarction has anesthetic and analgesic effects. Contraindications to the use of drugs: hypersensitivity to any component of the drug substance, hypersensitivity to amide type local command environment hypovolemia, command environment contraindications for local use, for I / regional anesthesia, paratservikalnoyi anesthesia in obstetrics. Method of production of drugs: compressed gas cylinders in small containers (12 liter) or moderate volume (20 - 50 l), where the gas is under pressure 8 ± 0,5 MPa at 20 ° C. Ekstubatsiya carried out at the first signs of consciousness, provided full recovery of here breathing. Method of command environment of drugs: Mr 100% of 100 ml or 250 ml vial.
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