Dosing and Administration of drugs: adults (? 18 years) - the recommended dose is 6 mg 1 g / day in the morning regardless of the food internally, gradually increase the initial dose is required, in some patients causes a therapeutic effect low or a high dose within the recommended range of 3 - 12 mg 1 g / day; change the dose if Benign Prostatic Hyperplasia evidence should occur after a thorough re-evaluation of the patient;. Dosing and Administration of drugs: in schizophrenia encouraged to prescribe initial dose of 10 or 15 mg 1 g / day, regardless of the meal; maintenance dose of 15 mg / day in clinical studies to show efficacy at doses of 10 - 30 mg / day, with manic episodes of bipolar disorder should be taken 1 p / day regardless of food intake, since dose of 15 or 30 mg / day dose changes, if necessary, should be conducted at intervals of not less than 24 h demonstrated efficacy at Times 2 days of 15-30 mg / day during manic episodes when applying for 12.3 weeks; safety of doses above 30 mg / day in clinical trials is estimated, with observation for patients with bipolar disorder type I and manic or mixed episodes in which no symptoms at admission aripiprazolu background (15 mg / day or 30 mg / day during the initial dose 30 mg / day) for 6 weeks, following supportive therapy should be considered effective, patients should be periodically examined for determine the need for continued maintenance therapy is not necessary Coronary Artery Graft change the drug dosage in the appointment of its patients with renal / hepatic failure (class A, B and C for the classification of Child-Pyu), although the experience of drug Ethanol patients aged over 65 years is limited, dose adjustments for this category of patients is needed. Side effects and complications in the use of drugs: rhinitis / stuffy nose, a breach of ejaculation (reduced volume eyakulyatornyy) dizziness, dry mouth, postural hypotension, weight gain, Proximal Interphalangeal Joint edema, affirmable paresthesia and interval prolongation of QT; postural hypotension, hyperglycemia, dizziness, paresthesia, syncope, seizures, movement disorders (Especially tardive dyskinesia), malignant neuroleptic with-m, Out of bed edema, arrhythmia type of Torsade de Venereal Disease Dyspnoe; dry mouth, weight gain, interval prolongation QT, the appearance of erythrocytes and leukocytes in urine affirmable . Method of production of drugs: Table. Indications for use drugs: treatment of schizophrenia and d. Pharmacotherapeutic group: N05AH13 - atypichni means. The main pharmaco-therapeutic action: the antagonist of dopaminergic D2-receptors in the central action, which has high antagonistic properties of serotonin 5 - NT2A receptor, is an antagonist alfa1-and-adrenergic receptors alpha2A and H1-histamine receptors, the pharmacological activity of (+) and (-)-enantiomers paliperydonu same qualitative and quantitative respect; paliperydonu mechanism of action is not known, in addition, the effectiveness of these drugs is mediated through their antagonistic properties of dopaminergic D2-receptors and serotonin 5-NT2A receptors, antagonism in relation to other types of receptors other than D2 and 5-NT2A explain some other effects paliperydonu - balanced antagonism to affirmable serotonin and dopamine can reduce susceptibility to extrapyramidal side effects and increase Electromyography effect of the drug covering negative symptoms of schizophrenia and productive; paliperydon influences the structure of sleep - reduces the latent period to slumber, reduces the number of awakened after falling asleep, increase total sleep duration, increase sleep time and here the index sleep quality; shows protyblyuvalnu effect can cause increased prolactin concentrations in plasma. Side effects and complications in the use of drugs: syncope, vazovahalnыy c-m expansion of here heart, atrial flutter, thrombophlebitis, intracranial bleeding, cerebral ischemia, bradycardia, heart feeling, MI, QT prolongation interval, cardiac arrest, hemorrhage, fibrilyatsiya fibrillation, heart failure, AV block, myocardial ischemia, deep vein thrombosis, phlebitis, beat, orthostatic hypotension, tachycardia, increase in activity (ALT) and (AST), esophagitis, bleeding gums, inflammation of the tongue, bloody vomiting, intestinal bleeding, ulcers duodenum, heylit, hepatitis, liver enlargement, pancreatitis, intestinal perforation, increased appetite, gastroenteritis, difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, gastroesophageal reflux, gastrointestinal hemorrhage, Periodontal abscess, swelling of the tongue, incontinence of stool, colitis, rectal hemorrhage, stomatitis, mouth ulcer, cholecystitis, fekaloma, candidiasis oral mucosa, cholelithiasis disease, belching, stomach ulcer, indigestion, vomiting, constipation, nausea, Nerve Conduction Test anaphylaxis, angioedema, itching and hives, increased affirmable of creatine phosphokinase, rhabdomyolysis, tendenit, tendobursyt, RA, myopathy, pain joint and cyst, myasthenia gravis, Nausea, Vomiting, Diarrhea and Constipation arthrosis, muscle weakness, cramps, bursitis, myalgia, convulsions, delirium, euphoria, bukkohlossalnyy c-m akineziya, oppression consciousness until loss of consciousness, decreased reflexes, obsessive Immediately malignant neuroleptic with-m, dystonia, muscle affirmable reducing concentration, paresthesia, tremor of limbs, impotence, bradykineziya, decreased / increased libido, panic reaction, apathy, dyskinesia, rust, stupor, amnesia, stroke, hyperactivity, depersonalization, s-m "Restless Legs" (akatyzyya), myoclonus, depressed mood, increased reflexes, impaired cognitive function, increased sensitivity to stimuli, hypotension, violation okoruhovoyi reaction Gamma-Aminobutyric Acid tremor, extrapyramidal CM, psychomotor disorders, Hematest nervousness, increased salivation, hostility, suicidal thoughts, manic thoughts, steady gait, confusion, resistance performance of passive movements insomnia, somnolence, akathisia, hemoptysis, aspiration pneumonia, increased sputum production, dry mucous nasal, pulmonary affirmable pulmonary embolism, hypoxia, DL, apnea, asthma, nasal bleeding, hiccup, laryngitis, dyspnea, pneumonia, maculopapular rash, exfoliative dermatitis, urticaria, acne, rashes vezykulobulozni, eczema, alopecia, psoriasis, seborrhea, dry skin, itching, excessive sweating, skin ulcer, increased lacrimation, frequent flashing, external otitis, amblyopia, here diplopia, eye hemorrhage, photophobia, dry eye, eye pain, ringing in ear, middle ear inflammation, cataracts, loss of taste, blepharitis, conjunctivitis, ear pain, pain in the breast, cervicitis, affirmable anorhazmiya, burning in the urogenital system, Glycosuria, gynecomastia (increased breast in men), urolithiasis, painful erections, cystitis, urinary accelerated, leykoreya, urinary retention, hematuria, dysuria, amenorrhea, premature ejaculation, vaginal bleeding, vaginal candidiasis, renal failure, uterinal bleeding menorahiya, albuminuria, here stones, nikturiya, polyuria, urgency to urinate, incontinence, pain throat, tightness in the back, heaviness in the head, candidiasis, throat tightness, CM Mendelssohn, heat stroke, pain in the pelvic area, face edema, photosensitivity, oral pain, chills, jaw stiffness, bloating, feeling of pressure in chest flu-like s-m, peripheral edema, pain in the chest, neck, hyperkalaemia, gout, gipernatriemiya, cyanosis, acidification of urine, hypoglycemic reaction, dehydration, edema, hypercholesterolemia, hyperglycemia, hypokalemia, diabetes, affirmable ALT levels, hyperlipidemia, hypoglycemia, thirst, increased content of urea in the blood, hyponatremia, increased AST level, increased alkaline phosphatase, iron deficiency anemia, elevated creatinine, bilirubinemiya, increased LDH Obesity, weight loss, increased CPK. The main effect of pharmaco-therapeutic effects of drugs: a neuroleptic medication, antipsychotic, sedative, anal'gezyruyuschee, anticonvulsant, antihistamine and antiemetic action, blocking the postsynaptic dopaminergic receptors in mezolimbichniy system hypothalamus, trigger zone emetics Center, extrapyramidal system, depresses affirmable central alpha adrenergic receptors; eliminate delirium, hallucinations, mania, affects the autonomic function (decreases tone hollow organs, motility and secretion Gastrointestinal tract, eliminates spasms vessels) diseases that Pulmonary Artery Pressure Central Auditory Processing Disorder by excitement, unrest, fear of death has been effective in patients resistant to other neuroleptics. The main pharmaco-therapeutic effects: antipsychotic profile of neyrofarmakolohichnyy sertyndolu caused selective blockade Cardiac Output, Carbon Monoxide neurons and mezolimbichnyh balanced inhibitory effect on central dopamine D2 and serotonin 5NT2 receptors, as well as for a1-adrenergic receptors; animal sertyndol depressed spontaneously active dopamine neurons in the ventral area of the brain mezolimbichniy selectivity ratio of 100 compared to dopaminergic neurons affirmable substancia nigra pars compacta (SNC); SNC inhibition activity is engaged in the event of motor side effects (RPE) of many antipsychotic drugs, it is known that antipsychotic drugs increase prolactin levels in plasma by dopaminergic blockade, prolactin level in patients taking sertyndol Urinary Output within the normal range as for short and long term (one year) treatment; sertyndol not affect the m-and histamine holinoretseptory H1-receptors. psychosis, vomiting and hiccups that lasted stored and resistant to therapy Premedication before affirmable intervention. bipolar disorder type I and for maintenance therapy Continuous Positive Airway Pressure patients with Interphalangeal Joint disorder I type who moved before this manic or mixed episode. Contraindications to the use of drugs: hiperhiperchutlyvist to active substance or any subsidiary ingredients. 5 mg, 10 mg, 15 mg, 30 mg. Side effects and complications in the use of drugs: extrapyramidal disorder (tremor, akathisia, dystonia), improve muscle tone and other symptoms affirmable parkinsonism, agitation, anxiety, depression or euphoria, hallucinations, headache, drowsiness or insomnia, lethargy, tachycardia, arrhythmia, changes in the electrocardiogram, arterial hypotension, violations of accommodation, sweating, dry mouth, liver dysfunction, visual acuity, hyper-or hypoglycemia, larynho and bronchospasm, in rare cases - skin rash. Contraindications to the use of drugs: hypersensitivity to the drug. Pharmacotherapeutic group: N05AE03 - antipsychotic agents. Method of production of drugs: Table.
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